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KMID : 1123920070210051260
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 5 p.1260 ~ p.1270
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Anti-allergic Effects of Socheongyoug-tang on RBL-2H3 Mast Cell and Mice-mediated Allergy Model
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Kim Kyung-Ryul
Lee Jong-Hwa
Kim Young-Jun
Choi Sung-Youl
Kim Tae-Heon
Lyu Yeoung-Su
Kang Hyung-Won
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Abstract
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The discovery of drugs on the treatment of mast cell-mediated allergic disease is a very important subject in human heath. The Socheongyoug-tang(SCYT) has been used for centruries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from SCYT on RBL-2H3 mast cell-mediated allergic reaction and studied its possible mechanism of action. SCYT inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. SCYT decreased the passive cutaneous anaphylaxis reaction activated by Anti-lgE antibody-HSA. SCYT dose-dependently reduced histamine release from mice peritoneal mast cells activated by Anti-lgE antibody-HSA. SCYT increased cAMP and decreased compound 48/80-induced intracellular levels. Our findings provide evidence that SCYT inhibits mast-derived allergic reactions, and also demonstrate the involvement of cAMP and intracellular in these effects.
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KEYWORD
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Socheongyoug-tang(SCYT), compound 48/80, cAMP, Anti-lgE antibody-HSA, allergy
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